2021 Softball Season Awards
DIVISION I
| First Team All Region | ||||
| # | Year | POS | Player | School |
| 18 | So. | C | Katriana Bain | Iowa Western |
| 10 | So. | P | Brook Melynchuk | Iowa Western |
| 4 | Fr. | P | Margot van Eijl | Indian Hills |
| 6 | Fr. | INF | Bryanna Mehaffy | Indian Hills |
| 6 | Fr. | INF | Lydia Allen-Barnes | Southeastern |
| 4 | So. | INF | Paige Shwaluk | Southwestern |
| 18 | So. | INF | Kaitlyn Schad | Southwestern |
| 9 | So. | INF | Chloe Olson | Indian Hills |
| 7 | Fr. | OF | Nicole Bellis | Indian Hills |
| 16 | Fr. | OF | Peyton Moffet | Indian Hills |
| 6 | So. | OF | Madeleine Shwaluk | Southwestern |
| 2 | So. | OF | Brylee Kemper | Southwestern |
| 8 | So. | UTL | Arianna Ramirez | Southeastern |
| 8 | So. | DP | Lexy Davis | Marshalltown |
| 16 | So. | DP | Abigayle Miller | Southeastern |
| Second Team All Region | ||||
| # | Year | POS | Player | School |
| 12 | So. | C | Dariann Diorio | Southeastern |
| 12 | Fr. | P | Thayda Houser | Southwestern |
| 10 | Fr. | P | Malarie Huseman | Indian Hills |
| 24 | So. | INF | Ali Enright | Southwestern |
| 11 | Fr. | INF | Reagan Emerick | Marshalltown |
| 5 | Fr. | INF | Mattilyn Reiling | Iowa Western |
| 12 | Fr. | INF | Gretta Hartz | Indian Hills |
| 8 | So. | INF | Jessica Strandlund | Iowa Western |
| 6 | So. | OF | Aujenai Gregory | Iowa Western |
| 4 | So. | OF | Trinity Krabill | Southeastern |
| 14 | Fr. | OF | Myla Beckstrom | Iowa Western |
| 8 | So. | OF | Hailey Chew | Southwestern |
| 10 | Fr. | UTL | Maggie Harrison | Marshalltown |
Player of the Year: Nicole Bellis, Indian Hills
Pitcher of the Year: Brook Melynchuk, Iowa Western
Offensive Player of the Year: Kaitlyn Schad, Southwestern
Defensive Player of the Year: Bryanna Mehaffy, Indian Hills
Coach of the Year: Lindsay Diehl, Indian Hills
Player of the Year:
DIVISION II
First Team All-Region
| Year | # | School | Name | Pos. |
| Fr. | 14 | Iowa Central | Madysen Lange | C |
| Fr. | 18 | Kirkwood | Peggy Klingler | C |
| Fr. | 22 | DMACC | Abby Flanagan | P |
| Fr. | 14 | Iowa Lakes | Lexi Chase | P |
| Fr. | 2 | Kirkwood | Kori Wedeking | P |
| Fr. | 20 | DMACC | Sophie Maras | INF |
| Fr. | 12 | DMACC | Kaylie Reynolds | INF |
| Fr. | 10 | DMACC | Delaney Kelley | INF |
| C-Fr. | 8 | Ellsworth | Gintare Paskocimaite* | INF |
| Fr. | 13 | Iowa Central | Loghen Schnetzer | INF |
| Fr. | 22 | Iowa Lakes | Eliya Johnson* | INF |
| So. | 10 | Kirkwood | Sydney Albaugh | INF |
| Fr. | 35 | DMACC | Abby Husak | OF |
| Fr. | 4 | Iowa Central | Carlie Thompson | OF |
| So. | 15 | Kirkwood | Randyn Carter | OF |
| So. | 20 | Kirkwood | Olivia Richards | OF |
| Fr. | 8 | DMACC | Jada Collins | DP |
| Fr. | 8 | NIACC | Laken Lienhard | UTL |
*At-Large Selections
Second Team All-Region
| Year | # | School | Name | Pos. |
| Fr. | 7 | NIACC | Hailey Worman | C |
| Fr. | 30 | Northeast | Brianna Aguilera | C |
| Fr. | 16 | DMACC | Lexi Lander | P |
| Fr. | 17 | Ellsworth | Delaney Vetter | P |
| Fr. | 17 | Kirkwood | Payton Akers | P |
| Fr. | 2 | DMACC | Sami Miller | INF |
| So. | 15 | Iowa Central | Mackenzie Rosenboom | INF |
| So. | 1 | Iowa Central | Abby Wilson | INF |
| Fr. | 3 | Kirkwood | Emilee Linder | INF |
| Fr. | 4 | Kirkwood | Austyn Crees | INF |
| Fr. | 18 | DMACC | Haley Forret | OF |
| Fr. | 11 | DMACC | Zoey Wright | OF |
| Fr. | 1 | Ellsworth | Kaysee Dale | OF |
| So. | 7 | Iowa Central | Abbie Thilges | OF |
| Fr. | 6 | Kirkwood | Angie Gorkow | DP |
| Fr. | 22 | Ellsworth | Chelsea Buck | UTL |
Honorable Mention All-Region
| Year | # | School | Name | Pos. |
| So. | 14 | Kirkwood | Jessie Frasher | C |
| Fr. | 25 | NIACC | Macy Alexander | C |
| Fr. | 14 | DMACC | Abby Archer | C |
| Fr. | 17 | DMACC | Ellie Jacobson | P |
| Fr. | 19 | Iowa Central | Madison Huisman | P |
| Fr. | 20 | NIACC | Kayla Sproul | P |
| C-Fr. | 6 | Ellsworth | Chloe Roberts | INF |
| So. | 20 | Iowa Central | Rachel Newell | INF |
| C-Fr. | 23 | Iowa Lakes | Kailey Maksim | INF |
| C-Fr. | 10 | Iowa Lakes | Kamryn Buntrock | INF |
| Fr. | 13 | Kirkwood | Reagan Schutte | INF |
| So. | 1 | Kirkwood | Alli Ferrari | INF |
| Fr. | 11 | NIACC | Anna Lensing | INF |
| Fr. | 14 | NIACC | Kayla Noelker | INF |
| Fr. | 2 | NIACC | Riley Nelson | INF |
| So. | 5 | Northeast | Alyssa Turner | INF |
| C-So. | 15 | Ellsworth | Gwen Hovorka | OF |
| So. | 17 | Iowa Central | Allyson Stewart | OF |
| Fr. | 9 | Kirkwood | Brooke Kilburg | OF |
| Fr. | 17 | NIACC | Kennadi Colbert | OF |
| Fr. | 11 | Northeast | Taylor Nicolay | OF |
| So. | 12 | Northeast | Chantel Julian | OF |
| Fr. | 28 | Iowa Central | Laila Pelds | DP |
| Fr. | 20 | Northeast | Greta Lindberg | DP |
| Fr. | 10 | Iowa Central | Mikhaela Muir | UTL |
Defensive Player of the Year: Randyn Carter, Kirkwood
Offensive Player of the Year: Sophie Maras, DMACC
Pitcher of the Year: Kori Wedeking, Kirkwood
Coach of the Year: Katie King, Iowa Lakes