Division I:
First Team All-Region:
| Name | School | Position | Year |
| Bailey Wiemann | Indian Hills | For. | Fr. |
| Elani Mears | Indian Hills | GK | So. |
| Risa Ogasawara | Indian Hills | Mid. | So. |
| Julia Herbst | Iowa Central | For. | So. |
| Elicia Mulvaney | Iowa Central | For. | So. |
| Alexis Vasquez | Iowa Lakes | St. | Fr. |
| Danielle Grimmer | Iowa Lakes | Def. | So. |
| Laura Linares | Iowa Western | Mid. | So. |
| Paula Boza | Iowa Western | Mid. | Fr. |
| Yoshiki Kitadai | Iowa Western | Mid. | Fr. |
| Judit Gonzalez | Iowa Western | GK | So. |
Honorable Mention All-Region
| Name | School | Position | Year |
| KJ Schmidt | Indian Hills | Def. | So. |
| Hope Ward | Indian Hills | Def. | Fr. |
| Yui Okamoto | Indian Hills | For. | So. |
| Anna Pons | Iowa Central | Mid. | So. |
| Flavie Sallaz | Iowa Central | Mid. | So. |
| Abigail Hersom | Iowa Central | Def. | Fr. |
| Bruna Kruschewsky | Iowa Lakes | St. | So. |
| Isabella Burger | Iowa Lakes | Def. | Fr. |
| Anna Hall | Iowa Western | Mid. | Fr. |
| Mayu Inokawa | Iowa Western | Def. | Fr. |
| Ririka Kamimura | Iowa Western | For. | Fr. |
Player of the Year: Laura Linares, Iowa Western
Coach of the Year: Adam Sanchez, Iowa Western
2021 All-Tournament Team
| Team | Name | School | Position | Year |
| All-Tournament | Alexis Vasquez | Iowa Lakes | Mid. | Fr. |
| All-Tournament | Laura Cardenas | Iowa Lakes | Def. | Fr. |
| All-Tournament | Falvie Sallaz | Iowa Central | Mid. | So. |
| All-Tournament | Addison Boyle | Iowa Central | Mid. | Fr. |
| All-Tournament | Laura Linares | Iowa Western | For. | So. |
| All-Tournament | Ririka Kamimura | Iowa Western | For. | Fr. |
| All-Tournament | Mayu Inokawa | Iowa Western | Mid. | Fr. |
| All-Tournament | Anna Hall | Iowa Western | Mid. | Fr. |
| All-Tournament | Risa Ogasawara | Indian Hills | Def. | Fr. |
| All-Tournament | Bailey Wiemann | Indian Hills | For. | Fr. |
| All-Tournament | Hope Ward | Indian Hills | Def. | Fr. |
| GK of Tournament | Judit Gonzalez | Iowa Western | GK | So. |
| Defensive MVP | Mayu Inokawa | Iowa Western | Mid. | Fr. |
| Offensive MVP | Ririka Kamimura | Iowa Western | For. | Fr. |
| Tournament MVP | Laura Linares | Iowa Western | For. | So. |
Division II:
First Team All-Region:
| Name | School | Position | Year |
| Alissa Merrick | Dakota County | Def. | Fr. |
| Charlotte Chalder | Hawkeye | Mid. | So. |
| Faith Cullen-Cooper | Hawkeye | Mid. | So. |
| Lauren Wagner | Hawkeye | Mid. | Fr. |
| Celine Witt | NIACC | For. | Fr. |
| Kailah Thompson | NIACC | Mid. | Fr. |
| Jessica Clinton | Northeast | Def. | Fr. |
| Mackenzie Byrnes | Northeast | GK. | So. |
| Naomi Pedroza | Northeast | For. | So. |
| Sara Pedroza | Northeast | For. | Fr. |
| Madison Gordon | Scott | Cam. | Fr. |
| Isabelle Hase | Southeastern | For. | Fr. |
| Taylor Ackerman | Southeastern | Mid. | Fr. |
Second Team All-Region:
| Name | School | Position | Year |
| Abigail Gotham | Dakota County | GK | Fr. |
| Lexi Wagner | Hawkeye | Mid. | Fr. |
| Riley Rosauer | Hawkeye | For. | Fr. |
| Summer Breed | Hawkeye | Def. | Fr. |
| Max De Armas Colombo | NIACC | GK | Fr. |
| Sophia Gebl | NIACC | Mid. | So. |
| Frida Aguilar-Ximello | Northeast | Mid. | So. |
| Hanna Cherven | Northeast | Def. | So. |
| Londyn Cacciacarne | Northeast | For. | So. |
| Madison Foutz | Northeast | Mid. | So. |
| Riley Walls | Scott | Def. | Fr. |
| Genevieve Berry | Southeastern | For. | Fr. |
| Mackenzie Kerns | Southeastern | Def. | Fr. |
Honorable Mention All-Region:
| Name | School | Position | Year |
| Lily Hernandez | Dakota County | For. | So. |
| Sierra Rudolph | Dakota County | Mid. | So. |
| Megan Birchall | Hawkeye | Def. | Fr. |
| Taryn Sutton | Hawkeye | Mid. | Fr. |
| Katie Cooling | NIACC | Mid. | So. |
| Mara Makowka | NIACC | Mid. | Fr. |
| Brianna Mendias | Northeast | Def. | Fr. |
| Kelsey Tabbert | Northeast | GK | So. |
| Aria Fix | Scott | For. | Fr. |
| Lauren Peet | Scott | CB. | Fr. |
| Sarah Morris | Southeastern | Def. | So. |
| Tara Patel | Southeastern | Def. | Fr. |
Player of the Year: Naomi Pedroza, Northeast
Coach of the Year: Chad Miller, Northeast
2021 All-Tournament Team
| Team | Name | School | Position | Year |
| All-Tournament | Brenda Vargas | Dakota County | Mid. | So. |
| All-Tournament | Madison Gordon | Scott | Mid. | Fr. |
| All-Tournament | Kailah Thompson | NIACC | Mid. | Fr. |
| All-Tournament | Jette Busche | NIACC | Def. | Fr. |
| All-Tournament | Jemma White | Southeastern | For. | Fr. |
| All-Tournament | Taylor Ackerman | Southeastern | Mid. | Fr. |
| All-Tournament | Lauren Wagner | Hawkeye | Mid. | Fr. |
| All-Tournament | Riley Rosauer | Hawkeye | For. | Fr. |
| All-Tournament | Lexi Wagner | Hawkeye | Mid. | Fr. |
| All-Tournament | Naomi Pedroza | Northeast | For. | So. |
| All-Tournament | Jessica Clinton | Northeast | Def. | Fr. |
| All-Tournament | Frida Aguilar-Ximello | Northeast | Mid. | So. |
| All-Tournament | Brianna Mendias | Northeast | Mid. | Fr. |
| GK of Tournament | Mackenzie Byrnes | Northeast | GK | So. |
| Defensive MVP | Jessica Clinton | Northeast | Def. | Fr. |
| Offensive MVP | Naomi Pedroza | Northeast | For. | So. |
| Tournament MVP | Naomi Pedroza | Northeast | For. | So. |