Division I:
First Team All-Region
| # | Name | School | Position | Year |
| 9 | Pablo Marques | Indian Hills | For. | So. |
| 10 | Lucas Hazi Pollacchi | Iowa Central | For. | So. |
| 10 | Sofian Maghouz | Iowa Lakes | Mid. | So. |
| 3 | Logan Roach | Iowa Lakes | Mid. | So. |
| 11 | Leonardo Seixas | Iowa Lakes | Mid. | So. |
| 1 | Yuta Ishizuka | Iowa Western | GK | So. |
| 17 | Ibrahim Conde | Iowa Western | For. | So. |
| 14 | Moise Bombito | Iowa Western | Def. | So. |
| 15 | Luka Nedic | Iowa Western | Mid. | So. |
| 9 | Gabriel Dias | Marshalltown | For. | So. |
| 27 | Jhancarlo Palma | Marshalltown | For. | Fr. |
Honorable Mention All-Region
| Team | Name | School | Position | Year |
| 1 | Matteo Scarduzio | Indian Hills | GK | Fr. |
| 17 | Giovani Kachan | Iowa Central | Mid. | Fr. |
| 5 | Federico Belintende | Iowa Central | Def. | Fr. |
| 6 | Jose Boggio | Iowa Lakes | Mid. | So. |
| 33 | Morris Duggan | Iowa Lakes | Def. | So. |
| 17 | Taurayi Tugwete | Iowa Lakes | Mf. | So. |
| 18 | Jiwoo Lee | Iowa Western | Mid. | So. |
| 27 | Giorgio Probo | Iowa Western | Mid. | So. |
| 20 | Mauki Kawahara | Iowa Western | Mid. | So. |
| 3 | Matheus Alves | Marshalltown | Def. | So. |
| 5 | Hiroki Tsuda | Marshalltown | Def. | Fr. |
Player of the Year: Luka Nedic, Iowa Western
Coach of the Year: Ben MacRae, Iowa Lakes
2021 All-Tournament Team
| Team | Name | School | Position | Year |
| All-Tournament | Lucas Hazi Pollacchi | Iowa Central | For. | So. |
| All-Tournament | Pablo Marques | Indian Hills | For. | So. |
| All-Tournament | Shogo Koike | Indian Hills | Def. | Fr. |
| All-Tournament | Hiroki Tsuda | Marshalltown | Def. | Fr. |
| All-Tournament | Gabriel Dias | Marshalltown | For. | Fr. |
| All-Tournament | Sofian Maghouz | Iowa Lakes | For. | So. |
| All-Tournament | Leonardo Seixas | Iowa Lakes | Mid. | So. |
| All-Tournament | Morris Duggan | Iowa Lakes | Def. | Fr. |
| All-Tournament | Claudel Ngongang | Iowa Western | Mid. | So. |
| All-Tournament | Joel Sangwa | Iowa Western | Def. | So. |
| All-Tournament | Giorgio Probo | Iowa Western | Mid. | So. |
| GK of Tournament | Yuta Ishizuka | Iowa Western | GK | So. |
| Defensive MVP | Carlos Santamaria | Iowa Western | Mid. | So. |
| Offensive MVP | Jiwoo Lee | Iowa Western | Mid. | So. |
| Tournament MVP | Moise Bombito | Iowa Western | Def. | So. |
Division II:
First Team All-Region
| Team | Name | School | Position | Year |
| 1st | Brandon Savage | Hawkeye | Def. | So. |
| 1st | Tbo Sotoyinbo | Hawkeye | For. | So. |
| 1st | Joe Farlow | Hawkeye | For. | Fr. |
| 1st | Alex Harris | Hawkeye | Def. | So. |
| 1st | Jimson St. Louis | Southeastern | For. | Fr. |
| 1st | Yohan Bernard | Southeastern | Def. | Fr. |
| 1st | Ryuga Uchigashima | Southeastern | Mid. | Fr. |
| 1st | Lee Donnellan | Scott | --- | Fr. |
| 1st | Logan Clendenen | Dakota County | Mid. | Fr. |
| 1st | Giovani Soares | NIACC | Mid. | Fr. |
| 1st | Nathan Skeete | NIACC | Mid. | So. |
| 1st | Paul Einero | Northeast | For. | Fr. |
| 1st | Chad Le Roux | Northeast | Def. | Fr. |
Second Team All-Region
| Team | Name | School | Position | Year |
| 2nd | Jaydon Joseph | Hawkeye | For. | Fr. |
| 2nd | Dilesh Patel | Hawkeye | Mid. | Fr. |
| 2nd | Joe Baston | Hawkeye | For. | So. |
| 2nd | Niall Chinn | Hawkeye | For. | Fr. |
| 2nd | Joep De Bruin | Southeastern | Def. | Fr. |
| 2nd | Jose Miranda | Southeastern | MF. | Fr. |
| 2nd | Kylian Leroy | Southeastern | GK | Fr. |
| 2nd | Isaac Almanza | Scott | --- | Fr. |
| 2nd | Prince Akonkoh | Dakota County | Def. | Fr. |
| 2nd | Axel Deligdisch | NIACC | For. | Fr. |
| 2nd | Lewis Bowes | NIACC | Mid. | So. |
| 2nd | Slayde Stokes | Northeast | Mid. | Fr. |
| 2nd | Jyson Breithbarth | Northeast | GK | So. |
Honorable Mention All-Region
| Team | Name | School | Position | Year |
| HM | Conal Burnett | Hawkeye | Def. | So. |
| HM | Bobby Robinson | Hawkeye | Def. | Fr. |
| HM | Alejandro Valverde | Southeastern | Def. | Fr. |
| HM | Nixon Valencia | Southeastern | Mid. | So. |
| HM | Jordan Kent | Scott | --- | So. |
| HM | Osvaldo Perez | Scott | --- | Fr. |
| HM | Cole Ayres | Dakota County | Def. | Fr. |
| HM | Ariel Kasonga Kashale | Dakota County | Mid. | Fr. |
| HM | Gian Lucca Scatolin | NIACC | Mid. | So. |
| HM | Cameron James | NIACC | Mid. | Fr. |
| HM | Mano Veldt | Northeast | Def. | So. |
| HM | Carlos Jimenez | Northeast | Def. | So. |
Player of the Year: Jimson St. Louis, Southeastern
Coach of the Year: Leo Driscoll, Hawkeye
2021 All-Tournament Team
| Team | Name | School | Position | Year |
| All-Tournament | Yamel Pantoja | Dakota County | For. | Fr. |
| All-Tournament | Nathan Skeete | NIACC | Mid | So. |
| All-Tournament | Giovani Soares | NIACC | Mid. | Fr. |
| All-Tournament | Paul Einero | Northeast | For. | Fr. |
| All-Tournament | Mano Veldt | Northeast | Def. | So. |
| All-Tournament | William Ansah | Hawkeye | Def. | So. |
| All-Tournament | Tbo Sotoyinbo | Hawkeye | For. | So. |
| All-Tournament | Joe Farlow | Hawkeye | For. | Fr. |
| All-Tournament | Alonso Miranda | Southeastern | Def. | Fr. |
| All-Tournament | Joel Perry | Southeastern | Gk | Fr. |
| All-Tournament | Jordan Kent | Scott | Mid. | So. |
| GK of Tournament | Juan Torres | Southeastern | GK | Fr. |
| Defensive MVP | Joep De Bruin | Southeastern | Def. | Fr. |
| Offensive MVP | Jimson St.Louis | Southeastern | For. | Fr. |
| Tournament MVP | Jimson St.Louis | Southeastern | For. | Fr. |