Division I:
First Team All-Region
| Name | School | Position | Year |
| Shogo Koike | Indian Hills | Def. | Fr. |
| Lucas Hazi Pollacchi | Iowa Central | - | Fr. |
| David Owusu | Iowa Lakes | For. | Fr. |
| Sebastian Zapata | Iowa Lakes | Def. | So. |
| Sofian Maghouz | Iowa Lakes | Mid. | So. |
| Ivan Callado | Iowa Western | For. | Fr. |
| Giorgio Probo | Iowa Western | Mid. | Fr. |
| Ibrahim Conde | Iowa Western | For. | Fr. |
| Patrick Millard | Iowa Western | GK | Fr. |
| Fumiya Shiraishi | Marshalltown | Mid. | Fr. |
| Guilherme Pereira | Marshalltown | Mid. | So. |
Honorable Mention All-Region
| Name | School | Position | Year |
| Ronaldo Carvalho | Indian Hills | Mid. | Fr. |
| Sebastian Hererra | Indian Hills | Mid. | Fr. |
| Danijel Bozic | Iowa Central | - | So. |
| Jose-Miguel Boggio | Iowa Lakes | Mid. | Fr. |
| Odal Brown | Iowa Lakes | Def. | So. |
| Taurayi Tugwete | Iowa Lakes | Mid. | So. |
| Vlad Jokic | Iowa Western | Mid. | So. |
| Evan Southern | Iowa Western | For. | Fr. |
| Maruki Kawahara | Iowa Western | Mid. | So. |
| Levi Vasconcelos | Marshalltown | Mid. | So. |
| Logan Mahecha | Marshalltown | Mid. | So. |
Player of the Year: Giorgio Probo, Iowa Western
Coach of the Year: Mike Brown, Iowa Western
2021 All-Tournament Team
| Team | Name | School | Position | Year |
| All-Tournament | Lucas Hazi Pollacchi | Iowa Central | --- | Fr. |
| All-Tournament | Fumiya Shiraishi | Marshalltown | Mid. | Fr. |
| All-Tournament | Guilherme Pereira | Marshalltown | For. | So. |
| All-Tournament | Leonardo Torcigliani | Indian Hills | Def. | So. |
| All-Tournament | Ronadldo Carvalho | Indian Hills | Mid. | Fr. |
| All-Tournament | Joel Quashie | Iowa Western | Mid. | So. |
| All-Tournament | Giorgio Probo | Iowa Western | Mid. | Fr. |
| All-Tournament | Joel Sangwa | Iowa Western | Def. | So. |
| All-Tournament | Moise Bombito | Iowa Western | Def. | Fr. |
| All-Tournament | Ben Thompson | Iowa Lakes | Def. | Fr. |
| All-Tournament | Sofian Maghouz | Iowa Lakes | Mid. | So. |
| All-Tournament | Oluwasamilola Olorunnisomo | Iowa Lakes | Def. | Fr. |
| GK of Tournament | Patrick Millard | Iowa Western | GK | RFr. |
| Defensive MVP | Joel Sangwa | Iowa Western | Def. | So. |
| Offensive MVP | Giorgio Probo | Iowa Western | Mid. | Fr. |
| Tournament MVP | Joel Quashie | Iowa Western | Mid. | So. |
Division II:
First Team All-Region
| Name | School | Position | Year |
| Cristian Fuentes | Dakota County | GK | So. |
| Ade Sotoyinbo | Hawkeye | For. | So. |
| Joe Baston | Hawkeye | For. | Fr. |
| Keith Gakaka | Hawkeye | For. | So. |
| Connor Lambert | NIACC | Def. | So. |
| Luke McMahon | NIACC | For. | So. |
| Breno Neves | Northeast | Def. | So. |
| Hugo Santos | Northeast | For. | Fr. |
| Trevor Millionzi | Scott | For. | So. |
| Bart Muns | Southeastern | For./Mid. | Fr. |
| Jair Arita | Southeastern | Def. | So. |
| Jimson St. Louis | Southeastern | For. | Fr. |
| Jotaro Mano | Southeastern | Mid. | Fr. |
Second Team All-Region
| Name | School | Position | Year |
| Dresden Gascho | Dakota County | Def. | Fr. |
| Alex Harris | Hawkeye | Def. | Fr. |
| Donald Holliday | Hawkeye | Def. | So. |
| Will Ansah | Hawkeye | Def. | So. |
| Caio Brito | NIACC | Mid. | So. |
| Lewis Bowes | NIACC | Mid. | Fr. |
| Carlos Jimenez | Northeast | Def. | Fr. |
| Jyson Breitbarth | Northeast | GK | Fr. |
| Arafath Ouro Gnao | Scott | For. | So. |
| Eric Benaigas | Southeastern | For. | Fr. |
| Joep De Bruin | Southeastern | Def. | Fr. |
| Larran De Almeid | Southeastern | Mid. | So. |
| Yohan Bernard | Southeastern | Def. | Fr. |
Honorable Mention All-Region
| Name | School | Position | Year |
| Miguel Dominguez | Dakota County | Mid. | So. |
| Sail Moo | Dakota County | For. | Fr. |
| Reon Dawes | Hawkeye | Mid. | So. |
| Sam White | Hawkeye | Mid. | So. |
| Axel Deligdisch | NIACC | For. | Fr. |
| Eddie Callanan | NIACC | Def. | Fr. |
| Mano Veldt | Northeast | Def. | Fr. |
| Samuel Holland | Northeast | Mid. | Fr. |
| Emmanuel Raya | Scott | For. | So. |
| Noah Cruz | Scott | CM | So. |
| Jeremy Guimbretiere | Southeastern | Def. | So. |
| Luiz Pontes | Southeastern | Mid./For. | So. |
Player of the Year: Bart Muns, Southeastern
Coach of the Year: Zac Newton, Southeastern
2021 All-Tournament Team
| Team | Name | School | Position | Year |
| All-Tournament | Griffin Tracey | Scott | - | Fr. |
| All-Tournament | Doh Junior | Dakota County | Def. | Fr. |
| All-Tournament | Luke McMahon | NIACC | For. | So. |
| All-Tournament | Hayden Bunch | NIACC | Mid. | So. |
| All-Tournament | Breno Neves | Northeast | Def. | So. |
| All-Tournament | Carlos Jimenez | Northeast | Def. | Fr. |
| All-Tournament | Jotaro Mano | Southeastern | Def. | Fr. |
| All-Tournament | Jimson St. Louis | Southeastern | For. | Fr. |
| All-Tournament | Jair Arita | Southeastern | Def. | So. |
| All-Tournament | Joep De Bruin | Southeastern | Def. | Fr, |
| All-Tournament | Keith Gakaka | Hawkeye | For. | So. |
| All-Tournament | Will Ansah | Hawkeye | Def. | So. |
| All-Tournament | Alex Harris | Hawkeye | Def. | Fr. |
| GK of Tournament | Whelan Joseph | Southeastern | GK | Fr. |
| Defensive MVP | Joep de Bruin | Southeastern | Def. | Fr. |
| Offensive MVP | Bart Muns | Southeastern | Mid. | Fr. |
| Tournament MVP | Bart Muns | Southeastern | Mid. | Fr. |