The annual ICCAC All-Region Teams for cross country are determined each year by their place at the Region XI Championships.
Iowa Central continued their dominance in Division I, with seven of the fifteen finishes this year to the All-Regional Team. Iowa Western provided five runners to the All-Region Team and Indian Hills rounded out the list accounting for three this year.
NIACC also continued its successful run in Division II with seven placements to the All-Region Team this year. Hawkeye also had a strong showing with five named to the list this year as well. DMACC followed with two selections, and Scott with one.
The 2021 Division I Male Athlete of the Year was Aspel Kiprob from Iowa Central. Kiprob received Athlete of the Week honors twice through the course of the ICCAC Cross Country Season. Kiprob placed third at the 2021 Greeno Dirksen Invite and second place finish at the All-American Invitational. The freshman was also the individual champion at the Jim Drews/Tori Neubauer Invitational. His performance at the Region XI Championships propelled him ahead of teammate Kelvin Bungei and Iowa Western's Nicholas Kiprotich, where he took first place at the meet.
The 2021 Division II Male Athlete of the Year was Melvin Kipkemboi from NIACC. This is the sophomore's second year being named to the All-Region Team and was selected as the Division II Men's Cross Country Athlete of the Week four teams this season. He was also selected as a National Athlete of the Week by the U.S. Track & Field and Cross Country Coaches Association.
Kipbemboi had several top five finishes this year and was the Division II individual champion at the 2021 Region XI Championships running a time of 24:28, over a minute better than his 2020 time.
Dee Brown of Iowa Central was named the 2021 Division I Men's Coach of the Year. This is the ninth consecutive year that Brown has won this award. Under Brown this year, the Iowa Central Titans won their ninth consecutive Region XI Championship and it is their tenth consecutive year having the individual region champion.
Curtis Vais of NIACC was named the 2021 Division II Men's Coach of the Year. Vais led the NIACC Trojans to the second consecutive team championship in Division II. Going into the Region XI Championships the Trojans are ranked ninth in NJCAA Division II. However, the Trojans are the reigning national championship for NJCAA Division II. They will head to Richmond, Va. on Nov. 13, along with the rest of the ICCAC, to defend their crown.
First Team All-Conference
| Name | School | Year | Hometown |
| Kelvin Bungei | Iowa Central | So. | Kitale, Kenya |
| Zander Cobb | Iowa Central | Fr. | Washington, MI |
| Aspel Kiprob | Iowa Central | Fr. | Nakuru, Kenya |
| Jaysen Bouwers | Iowa Western | Fr. | Sioux City, IA |
| Nicholas Kiprotich | Iowa Western | Fr. | Eldoret, Kenya |
| Yonas Mogos | Iowa Western | So. | Aurura, CO |
| Melvin Kipkemboi | NIACC | So. | Rift Valley, Kenya |
Second Team All-Conference
| Name | School | Year | Hometown |
| Isaac Bryant | Indian Hills | So. | --- |
| Colton Glosser | Indian Hills | So. | Packwood, IA |
| Nick O'Connor | Indian Hills | So. | Tiffin, IA |
| Brady Hogan | Iowa Central | Fr. | Waukon, IA |
| Yared, Kidane | Iowa Central | So. | Eskilstuna, IA |
| Hunter Klimek | Iowa Central | So. | Motley, MN |
| Wimachmorr Gilo | Iowa Western | So. | Council Bluffs |
Honorable Mention All-Conference
| Name | School | Year | Hometown |
| D'Artagnon Beaver | Hawkeye | Fr. | Rockford, IL |
| Brady Millikin | Indian Hills | Fr. | Hedrick, IA |
| Robi Agilar-Gonzalez | Iowa Central | Fr. | Liberia |
| Merci Bita | Iowa Western | Fr. | Sioux Falls, SD |
| Ryker Mattioli | Iowa Western | Fr. | Durham, NC |
| Zach Rathburn | Iowa Western | Fr. | North Port, FL |
| John Swotek | Iowa Western | Fr. | Lincoln, NE |
2021 ICCAC All-Region
Division I
2021 First Team All-Region
| Name | School | Year | Hometown |
| Aspel Kiprob | Iowa Central | Fr. | Nakuru, Kenya |
| Kelvin Bungei | Iowa Central | So. | Kitale, Kenya |
| Zander Cobb | Iowa Central | Fr. | Washington, MI |
| Nicholas Kiprotich | Iowa Western | Fr. | Eldoret, Kenya |
| Jaysen Bouwers | Iowa Western | Fr. | Sioux City, IA |
2021 Second Team All-Region
| Name | School | Year | Hometown |
| Isaac Bryant | Indian Hills | So. | |
| Hunter Klimek | Iowa Central | So. | Motley, MN |
| Yared, Kidane | Iowa Central | So. | Eskilstuna, IA |
| Yonas Mogos | Iowa Western | So. | Aurura, CO |
| Wimachmorr Gilo | Iowa Western | So. | Council Bluffs, IA |
2021 Honorable Mention All-Region
| Name | School | Year | Hometown |
| Nick O'Connor | Indian Hills | So. | Tiffin, IA |
| Colton Glosser | Indian Hills | So. | Packwood, IA |
| Brady Hogan | Iowa Central | Fr. | Waukon, IA |
| Robi Aguilar-Gonzalez | Iowa Central | Fr. | Liberia |
| Ryker Mattioli | Iowa Western | Fr. | Durham, NC |
Division I - Athlete of the Year - Aspel Kiprob, Iowa Central
Division I - Coach of the Year - Dee Brown, Iowa Central
Division II
2021 First Team All-Region
| Name | School | Year | Hometown |
| D'Artagnon Beaver | Hawkeye | Fr. | Rockford, IL |
| Melvin Kipkemboi | NIACC | So. | Rift Valley, Kenya |
| Christain Rodriquez | NIACC | Fr. | Mason City, IA |
| Peyton Seiler | NIACC | Fr. | Gering, NE |
2021 Second Team All-Region
| Name | School | Year | Hometown |
| Tyler Colvin | Hawkeye | So. | Marion, IA |
| Cooper Olsen | Hawkeye | Fr. | Cedar Falls, IA |
| Bryden Juelsgaard | NIACC | So. | Cresco, IA |
| Richard Marcoux | NIACC | So. | Omaha, NE |
2021 Honorable Mention All-Region
| Name | School | Year | Hometown |
| Harrison Vanderlinden | Hawkeye | So. | Marion, IA |
| Stephen Thomas | Hawkeye | Fr. | Rockford, IL |
| Caleb Sledd | NIACC | So. | Osage, IA |
| Noah Smith | Scott | So. |
Division II Athlete of the Year - Melvin Kipkemboi, NIACC
Division II Coach of the Year - Curtis Vais, NIACC